Scientific Program

Conference Series Ltd invites all the participants across the globe to attend Asian Global Summit on Heart and Emergency Medicine Kyoto, Japan.

Submit your Abstract
or e-mail to

globalheartcongress@asia-meetings.com

Scientific Program Day 1

Day 1 :

  • Clinical Cardiology

Session Introduction

Stefan Spasic

University of defence in Belgrade, Serbia

Title: The most common comorbities in patient with pulmonary tromboembolism and possible imact on mortality
Biography:

Stefan Spasis is as student of Medical faculty, age 24. He has been an autor and coautor in many scientific research papers, also he he has parpicipated in student congresses at home and abroad.

Abstract:

Pulmonary thromboembolisms are very often associated with various comorbidities and they contribute to the development of PE in a varying degree and can significantly affect the outcome.
To determine which comorbidities accompany pulmonary thromboembolism and how they affect the mortality of patients with it.The study included 356 patients with pulmonary thromboembolism who were admitted to the Emergency Medicine Clinic from September 2011 to September 2017, with an average age of 64 + -11 years, of which there were more men ( 50,8%). They are divided into six groups based on their comorbidities (symptomatic vascular disease, surgery /trauma, psychoneurological diseases, malignancies, infections, chronic inflammatory diseases).: Most patients were classified into surgery/trauma group (29.88%), while the least of them had an infection (11.24%). The highest mortality was in the group with malignant disease (23.49%), but this was not statistically significant (p = 0.90). Also, there was no statistically significant difference in mortality between healthy and those with one comorbidity (p = 0.72), while there was significant difference in those with one and two comorbidities (p = 0.00017), as well as between healthy and those with two comorbidities (p = 0.0004).: A large number of comorbidities accompany or cause pulmonary thromboembolism and also impair the survival of these patients. Therefore, it is important to pay attention to its prevention in all those who have at least one criteria of Virhov's triad fulfilled.
 

Ma. Niña P. Castillo

Ilocos Training and Medical Center, Philippines

Title: Ruptured Dilated Right Coronary Sinus of Valsalva with Ventricular Septal Defect
Biography:

Ma. Niña P. Castillo is a Resident Physician in Internal Medicine at the Ilocos Training & Regional Medical Center, San Fernando, La Union, Philippines

Abstract:

Ventricular septal defects account for 10 percent of congenital heart diseases in adults. They can either occur alone, or in combination with other cardiac anomalies. Ventricular septal defects, and more commonly aortic valve regurgitation and bicuspid aortic valve, are frequently associated with ruptured sinus of Valsalva aneurysms. Rupture of the aneurysm is the most common complication, which commonly protrude and rupture into the right ventricle or right atrium. 
We present the case of a 27-year old male who was admitted because of lightheadedness and dizziness. The patient had a history of a heart murmur since childhood and was diagnosed with a congenital heart disease. 2D-echocardiography with Doppler studies revealed a dilated right coronary sinus of Valsalva with rupture into the right ventricular outflow tract
 

Ann Crizette R. Garcia

The Medical City, Ortigas Avenue, Pasig City, Philippines

Title: A Case Report of Ortner’s Syndrome secondary to Aortic Arch Aneurys
Biography:

Ann Crizette R. Garcia is currently working in The Medical City, Ortigas Avenue, Pasig City, Philippines.

Abstract:

zhen wang

Zhejiang University, China

Title: Piceatannol alleviates high glucose/high lipid-induced vascular dysfunction by MAPK signal transduction pathway
Biography:

Zhen wang has completed her MASTER at the age of 28 years from Zhejiang University and  now she is studing for PhD at Zhejiang University.She has published more than 2 papers in SCI journals.

Abstract:

Background: Endothelial dysfunction considered as an initial and developing event in the progression of atherosclerosis in patients with metabolic syndrome. Piceatannol have cardioprotective effects and anti-inflammatory properties in several diseases. In the present study, we investigated whether piceatannol provides beneficial effects on hyperglycemia /hyperlipidemia-induced dysfunction of endothelial cells and explored the possible molecular mechanisms. Methods: Human umbilical vein endothelial cells (HUVECs) were exposed for 72h to high-glucose/high lipid (HG/HL) using dextrose (33 mmol/L) and the saturated free fatty acid palmitate(500 mmol/L) , with or without pre-treated of piceatannol (10uM) for 24h. HUVEC viability, proliferation and migration were determined. Protein expression of endothelial intercellular adhesion molecules (ICAM-1), endothelial nitric oxide synthase (eNOS) were measured by Western blot and some key signalling pathways that regulate endothelial cell function were also characterized.. Results: We found that hyperglycemia and hyperlipidemia resulted in significantly impaired endothelial cells function as shown by the reduction of HUVEC viability, proliferation, cell migration and the protein level of the phospho-endothelial nitric oxide synthase (p-eNOS). Dextrose and the saturated free fatty acid palmitate stimulation of HUVECs increased the level of the Intracellular adhesion molecule 1 (ICAM-1) and accelerated endothelial senescence. These effects of hyperglycemia and hyperlipidemia were inhibited by pretreatment with piceatannol for 24h. These beneficial effects of piceatannol on the endothelium were associated with MAPK and NF-KB pathways. Conclusion: Piceatannol, via increasing the protein level of the phospho-endothelial nitric oxide synthase (p-eNOS), reserving the function of cell viability, proliferation, cell migration, decreasing endothelial senescence, down-regulating the level of the adhesion molecules (ICAM-1), suggests that picetannol exerts beneficial effects on hyperglycemia and hyperlipermia induced endothelial cell dysfunction through regulation of the MAPK families and NF-KB pathway.